Endocrine Abstracts

Transient insulin resistance (IR) is a recognized facet of metabolic phenotype in pubertal boys. However, it remains unknown how the Y chromosome and adolescence as a transition from pubertal period to adulthood affects markers of insulin resistance, particularly in relation to body mass index, blood pressure and androgens.We analyzed associations among indicators of insulin resistance, total adiposity, androgen profile and the Y chromosome in a sample of 1745 males divided in...

Males display an increased level of cardiovascular morbidity and mortality than age matched females. Among the genetic factors responsible for the relationship between higher cardiovascular risk and male gender are the sex chromosomes. In this study we investigated the association between serum lipid profile and a polymorphism on the non-recombining region of the human Y chromosome in a population of young Caucasian individuals. 1157 young males were recruited form the general...

Objective: To examine if there was an association between blood pressure and two polymorphic markers, M9 (CtoG) and HindIII in the non-recombining region of the Y chromosome.Design and Methods: 204 pedigrees all including hypertensive individuals were collected from the south of Poland after local Ethical committee approval. Phenotypic data including hypertensive status as well as BP, weight and height were collected. We phenotyped and genotyped 155 unr...

Objective: Three nonsynonomous SNPs, Arg16Gly, Gln27Glu and Thr164Ile, in the coding region of the ADRB2 gene affect either receptor affinity or trafficking. Their distribution has been shown to differ significantly in hypertension. We investigated the association of these loci with hypertension in the Silesian Hypertension Study.Methods: Following local ethics approval, 274 unrelated Polish subjects consisting of 146 hypertensives and 128 normotensives ...